1. Genomics Unit. Laboratory of Genomics and Microarrays (LABGEN)
The main objective of the Genomics and Microarrays Laboratory is to contribute to the integration of high-throughput genomic analysis technologies in hospital practice in order to personalise clinical decision-making through the discovery of prognostic and predictive biomarkers of drug response (pharmacogenomics). The advances in medicine brought about by the knowledge of the human genome and the development of technologies such as microarrays are leading to unprecedented progress in the possibilities and clinical management of patients. These methodologies are essential especially in multifactorial pathologies, where classification by traditional histopathological methods is insufficient to predict the course to be taken or to study the suitability of the treatment to be followed. Molecular markers identified following a genomic study combined with clinical factors provide information that has the potential to identify unique characteristics of each individual, and therefore, personalise the clinical strategies to be applied.
The Genomics and Microarrays Laboratory is a member of the Network of Laboratories of the Community of Madrid, with registration number 325.
2. Genomics Unit. Laboratory of Molecular Oncology (LABINMUNO)
Laboratory of Molecular Oncology: Study of genetic susceptibility to cancer and study of molecular biomarkers.
3. Genomics Unit. Laboratory of Immunogenetics and Sequencing (LABINMUNO)
4. Genomics Unit. Microbiota Laboratory (LABMIC)
Our knowledge about the composition and functions of the microbiota is currently growing exponentially, largely due to the development of so-called Next Generation Sequencing (NGS) technologies that allow the analysis of the genetic and metabolic profiles of entire microbial communities without the need for culture (metagenomics). The Microbiota STU offers the possibility to analyse the biodiversity and study the abundance of microorganism species in an ecosystem, as well as to identify bacterial proteins with specific functionalities or enzymatic activities.
This STU is created with the conviction that, in the not-too-distant future, knowledge of our microbiota will help us to create another dimension of personalised medicine, leading to better diagnostics, prognostics and therapeutics for patients.
Dra. Beatriz Pérez-Villamil
beatriz.perezvillamil@salud.madrid.orgGuillermo Velasco Díez
gvd@bbm1.ucm.esMiguel Fernández Arquero
Servicio de Inmunología
Instituto de Medicina de Laboratorio
mfarquero@salud.madrid.orgDulcenombre Gómez Garre.
mgomezg.hcsc@salud.madrid.org
A: Genomics Unit. Laboratory of Genomics and Microarrays (LABGEN)
B: Genomics Unit. Laboratory of Molecular Oncology (LABINMUNO)
C: Unidad de Genómica. Laboratorio de Inmunogenética y Secuenciación (LABINMUNO)
D: Genomics Unit. Microbiota Laboratory (LABMIC)
These services have approved fees in force.
Click here to download the tariffs (PDF).
HCSC:
Lipids and Hypertension Unit.
Medical Oncology Department (Clinical Trials).
Immunology Clinical Management Unit (Clinical Trials).
Microbiology Department (Clinical Trials).
Any user interested in studying the composition of the gut microbiota by massive sequencing techniques.
The Biobank is attached to 2 external committees:
YEAR | PUBLICATION | TITLE |
2012 | BMC Cancer, vol. 12, no. 1. p. 260, 2012 | Colon cancer molecular subtypes identified by expression profiling and associated to stroma, mucinous type and different clinical behavior, |
2015 | Nat. Med., Nov;21(11):1350-6, 2015 | The consensus molecular subtypes of colorectal cancer |
The Genomics and Microarrays Laboratory is a member of the Network of Laboratories of the Community of Madrid, with registration number 325.
• Master’s Thesis in Translational Medicine (UCM):
Effect of bariatric surgery on the composition of the intestinal microbiota of morbidly obese patients. Comparison of gastric bypass and SADI-S techniques. Grade: 9.6.
• Master’s Thesis in Bioinformatics and Computational Biology (UAM):
Development of a pipeline for the analysis of metagenomic data obtained by sequencing multiple variable regions of the 16S rRNA gene by massive sequencing. Qualification: 9.7.
• Master’s Thesis in Translational Medicine (UCM):
Role of the intestinal microbiota in the development of heart failure in a hypertensive rat model. Grade: 10.
• Doctoral thesis at the Faculty of Medicine of the UCM:
Study of the relationship of bacterial metabolites trimethylamine N-oxide and trimethylamine with cardiovascular disease and renal function in HIV-infected patients. Qualification: Outstanding cum laude unanimously.
• Final Degree Project in Biology (UCM):
Analysis of the intestinal microbiota in an experimental model of multiple sclerosis. Grade: 8.5.
• Master’s Thesis in Microbiology (UAM):
Role of intestinal microbiota in acute myocardial infarction associated or not with obesity. Grade: 9.5.
• Master’s Thesis in Microbiology (UAM):
Effect of a mitochondrial antioxidant on gut microbiota in obesity. Grade: 10.