Clinical and Translational Research in Oncology

Strategic objectives

The following institutions will be eligible for financing through the ISCIII:

  • Development and maintenance of the clinical trials platform (Phases I, II, and III).
  • To continue to be a reference unit in the analysis of susceptibility genes in the most common tumours.
  • To consolidate the platform of prognostic and predictive biomarkers of therapeutic targets in colon cancer.
  • To consolidate the CTC (circulating tumour cell) platform in breast and colon cancer, and to develop it in other tumours such as lung and prostate.
  • To continue to be a leading group within the Research Network of Cancer Centres (RTICC) of the Instituto Carlos III.

Lines of research

  • Identification of predictive response factors and new therapeutic targets in colon, breast, glioma, and prostate cancer, and design and analysis of the efficacy of new therapies in preclinical models of these tumours.
  • Pharmacogenomic study of predictive factors of response and toxicity in colon, breast, and lung cancer. Analysis of global gene expression. Study of molecular pathological, pharmacodynamic, and pharmacogenetic determinants.
  • Liquid biopsy and biomarkers: a) Biomarkers in liquid biopsy (circulating nucleic acids, circulating tumour cells, vesicles) in cancer patients. Potential use as non-invasive prognostic and predictive biomarkers; b) Mechanistic analysis of circulating nucleic acids in vesicles in the tumour environment, and their influence on tumourigenic processes.
  • Molecular mechanisms of genetic susceptibility to cancer (breast-ovarian syndrome and Lynch syndrome).
  • Microarray and microRNA platform.

 

Research lines in PATHOLOGYCAL ANATOMY

  • Digestive cancers
  • Cutaneous neoplasms in immunocompromised individuals
  • Cancer immunopathology
  • Celiac disease
  • Inflammatory bowel disease
  • Study of biomaterials in bone

Other members of the group

  • Virginia Acedo Jimenez
  • Carlos Aguado De La Rosa
  • María Del Rosario Alfonso San Segundo
  • David Alonso Prieto
  • Marta Amann Arévalo
  • Inmaculada Bando Polaino
  • Patricia Barreiro Sanabria
  • Jorge Bartolomé Arcilla
  • Javier David Benitez Fuentes
  • Alberto Benito Martín
  • Sara Cañas Herrera
  • Santiago Cabezas Camarero
  • Susana Campuzano Ruiz
  • Laura Carrasco Sánchez
  • Isabel Casado Fariñas
  • Antonio Casado Herráez
  • Mª De Los Angeles Ceron Nieto
  • Marco Ciappara Paniagua
  • Belén Cobaleda Esteban
  • Ana María Colino Gallardo
  • Juan Antonio Corona Sánchez
  • José Antonio Cortés Toro
  • Cristina Díaz-Tejeiro Rodríguez
  • Miguel De La Hoya Mantecón
  • Montserrat De La Torre Serrano
  • David De Pablo Velasco
  • Paula Diaque García
  • Cristina Diaz Del Arco
  • Ada Esteban Sánchez
  • Raquel Fernandez Blanco
  • Lorena Fernandez Montarroso
  • María Jesus Fernandez Aceñero
  • María Begoña Ferrer Meseguer
  • Carlos Alfredo Fraile Olivero
  • Jesús Fuentes Antrás
  • Alicia Fuentes Martín
  • Alicia Gómez Sanz
  • María Elena Gómez Del Pulgar Gutiérrez
  • Mª Isabel Galante Romo
  • Laura García Bravo
  • Beatriz García Paredes
  • José Ángel García Sáenz
  • Alicia García Montes-Jovellar
  • Vanesa García Barberán
  • Miguel Ángel García Brenes
  • Ricardo García Martínez
  • María García Rodríguez
  • Dolores Garcia Lopez
  • Pilar Garre Rubio
  • Adrián Garrido Hernández
  • Juan Gomez Rivas
  • José Luís González Larriba
  • Paula González Heras
  • Maria Luisa Gonzalez Morales
  • Sandra Gutiérrez García
  • María Helena Huertas Mondejar
  • Elena López Calzada
  • Igor Gregorio López Cade
  • Miguel López García
  • Alfonso López De Sá Lorenzo
  • Estela Labad Delgado
  • Ana Paula Leiva Asenjo
  • Víctor Lorca Castellanos
  • Gloria Marquina Ospina
  • Melody Marrero García
  • Miquel Martínez Fontanillas
  • Ana Martínez Rodríguez
  • María Mateos González
  • José Manuel Morales Gómez
  • María Teresa Moreno Fernández
  • Fernando Moreno Antón
  • Marina Moreno Mayorga
  • Jesús Moreno Sierra
  • Ignacio Moreno Pérez
  • Cristina Nieto Jiménez
  • Elena Nuñez González
  • Alberto Ocaña Fernandez
  • Helena Olivera Pérez-Frade
  • Alberto Orta Ruiz
  • Luis Ortega Medina
  • Natalia Pérez Romero
  • Beatriz Pérez-Villamil Salgado
  • Lucía Paniagua Herranz
  • Daniel Parra Corral
  • Mateo Paz Cabezas
  • Jose Manuel Pingarron Carrazon
  • José Carlos Plaza Hernández
  • Javier Puente Vázquez
  • Sara Rafael Fernández
  • Lobna Ramadane Morchadi
  • Enrique Redondo Gonzalez
  • Sandra Rico Galve
  • Adrián Rodríguez Manzanedo
  • Raquel Rodríguez Damiano
  • Eva Rodríguez Escudero
  • Pablo Rodríguez Olmedo
  • María Carmen Sáez Rodríguez
  • Melchor Saiz-Pardo Sanz
  • Teresa Salas García-Talavera
  • Jesús María Salinas Casado
  • Passio Beatriz Santos Capa
  • Adrián Sanvicente García
  • Javier Sastre Valera
  • Jose Luis Senovilla Perez
  • Alvaro Serrano Pascual
  • Maria Luisa Suarez Solis
  • Manuel Gonzalo Vázquez Masedo
  • Natalia Vidal Cassinello
  • Marta Vidaurreta Lázaro

Publications

Projects