Endocrinology of Metabolic Diseases

+ Info

PRINCIPAL INVESTIGATOR

Alfonso Calle Pascual
alfonsoluis.calle@salud.madrid.org
Tel. +34 913303000 (Ext. 483127)
Miguel Angel Rubio Herrera
ADDRESS

Endocrinology and Nutrition

1ªS. San Carlos Clinical Hospital
C/ Profesor Martín Lagos s/n. 28040 Madrid

Group information

The Endocrinology Research Group in Metabolic Diseases is designed to facilitate research applied to clinical practice in patients with disorders related to endocrinology and nutrition, also covering preventive aspects of non-communicable chronic diseases. Additionally, it has the capability to explore the molecular mechanisms involved in these pathologies using the equipment available in the service’s laboratory and through its connection with the Complutense University of Madrid.

Its mission is to encourage research from all perspectives of endocrinology and nutrition, adhering to good clinical practices and promoting a translational approach to the results obtained.

The group will be involved in monitoring research efficiency, which will be managed through the highest governing bodies of the center or associated healthcare centers.

The group is expected to continue being recognized as a national leader in research on endocrinology and nutrition within its areas of expertise.

Strategic objectives

Conduct collaborative research with other research groups in areas such as diabetes mellitus and new technologies, metabolic syndrome, obesity, disease-related malnutrition, eating disorders, neuroendocrine tumors, thyroid and parathyroid pathology, neurohypophysis disorders, hyperaldosteronism, hyponatremia and disorders of body water, and transgender patients.
Participate in national disease registries, generating knowledge in collaboration with other national and international research groups: NADYA, National Detransition Registry, National Registry on the Diagnosis and Treatment of Hyponatremia: AQUA-SPAIN Registry, and type 1 diabetes mellitus.
Publish at least three articles annually in high-impact journals.
Develop doctoral theses related to the group’s areas of expertise.
Participate in consensus statements and clinical practice guidelines within the specialty.

Lines of research

Epidemiology of diabetes mellitus and its complications.
Effectiveness of the Mediterranean diet in the prevention of gestational diabetes and associated metabolic diseases.
Long-term outcomes for patients with gestational diabetes, considering the clinical impacts on their offspring.
Evolution of metabolic syndrome following an intervention based on the Mediterranean diet.
Biomarkers associated with food intake.
Changes in signals mediated by gastrointestinal hormones and neuropeptides in appetite control mechanisms following bariatric surgery.
Factors influencing body weight regulation in obesity: analysis of gastrointestinal hormones and encoding genes.
Role of bariatric surgery in the treatment of morbid obesity and remission of diabetes mellitus.
Evolution of body composition and prevalence of sarcopenic obesity in patients after bariatric surgery.
Inflammation and oncogenesis in metabolic diseases.
Molecular biology related to obesity, diabetes, vascular risk, and cancer.
Pharmacogenetics of somatostatin analogs in patients with gastroenteropancreatic neuroendocrine tumors: study of polymorphisms, somatic mutations, and proteins involved in tumor response.
Therapeutic optimization protocols in clinical nutrition for hospitalized and outpatient patients.
Prevalence of disease-related malnutrition in oncology patients: body composition.
Clinical nutrition interventions and their impact on clinical outcomes, physical function, and body composition.
Metabolic changes occurring after hormonal treatment in transgender and gender-diverse populations.
Causes and consequences of hyponatremia and body water disorders.
Thyroid nodule: benign and oncological pathology.
Hyperaldosteronism: characterization and treatment.