Infectious Diseases/HIV

Strategic objectives

  • Maintain our own research projects on HIV: further develop the ongoing lines of research on comorbidities. Specifically, the lines that have already been initiated are: Cardiovascular disease (hypertension, carotid intima-media thickness progression, HDL function, microRNA); muscle weakness, frailty, osteoporosis, and aging in HIV patients; depression in patients with HIV infection; and role of gut microbiota in chronic inflammation and HIV-associated complications.
  • Develop a European research project on comorbidities/aging in HIV patients
  • Maintain our own projects on viral hepatitis, focusing on the response to HCV treatment and the epidemiological aspects of HIV/HCV coinfection
  • Develop our own projects in other infectious diseases: establish a research line in the field of tuberculosis
  • Maintain a steady number of clinical trials from the pharmaceutical industry or research consortia to ensure the financial support of the group’s contracted personnel
  • Publish at least 2-3 original articles per year
  • Incorporate predoctoral researchers into the group, especially medical residents upon completing their training period
  • Conduct research projects on HIV/STIs: develop lines of research on HIV epidemiology, specifically: adult cohorts, controllers, LTNP (long-term non-progressors), acute infection, and the profile of new diagnoses; preventive antiretroviral therapy and studies on PrEP users
  • Follow-up on studies regarding the epidemiology and treatment of STIs
  • Maintain projects on the epidemiology of viral hepatitis, acute HCV infection, HIV/HCV coinfection, and HIV/HBV coinfection
  • Follow-up on the research line of preventive and reproductive counseling for HIV serodiscordant couples. Effectiveness of antiretroviral treatment on sexual transmission of HIV in homosexual and heterosexual serodiscordant couples (TasP)
  • Secondary prevention of anogenital cancer (HPV)
  • Conducting clinical trials sponsored by the pharmaceutical industry and public entities
  • Maintain cohorts of HIV-positive children and pregnant women in the Community of Madrid
  • Integration of pediatric HIV and HCV coinfection cohorts with adult cohorts
  • Continue participation in PENTA clinical trials for antiretrovirals and other antimicrobials
  • Enhance phase I-II trials of antimicrobials
  • Maintain and enhance research by all members in the development of pediatric drugs

Lines of research

Comorbilities associates to HIV infection

  • Cardiovascular disease
  • Metabolic alterations
  • Pathogenesis of aging in HIV patients
  • Role of the gut microbiota in chronic inflammation and HIV-associated complications

 

HIV reservoirs

  • Association with comorbidities and chronical inflammation
  • Association with immunological recovery

 

Clinical studies in patients with ongoing HIV treatment

  • Stratification of complexity
  • Lost to follow-up
  • Quality of life and stigma associated with HIV
  • Pain related to the administration of injectable medications

 

Intestinal microbiota

  • Recurrent STIs
  • Nosocomial infections

 

Respiratory infections requiring hospitalization (RIH)

  • Clinical characteristics of adult patients with RSV and influenza
  • Missed opportunities with Paxlovid
  • Cardiovascular complications of respiratory infections requiring hospitalization (RIH)

 

Studies in general infectious diseases

  • Osteoarticular infection
  • Pulmonar tuberculosis
  • Viscera leishmaniasis
  • Infections in patients with pharmacological immunosuppresion

Other members of the group

  • María Inés Armenteros Yeguas
  • Juan Ballesteros Martin
  • Julia Barrado Cuchillo
  • Begoña Baza Caraciolo
  • Arantxa Berzosa Sanchez
  • Andrés Bodas Pinedo
  • Marta Bote Gascón
  • Noemi Cabello Clotet
  • Paula Cabrera Cascajero
  • Yolanda Campanero Núñez
  • Maravillas Carralón González
  • Dulce Carrio Montiel
  • Petunia Clavo Escribano
  • Enrique Criado Vega
  • Geni Constanza Díaz Hernández
  • Olivia De La Calle Jiménez
  • Santiago Fernández Castelao
  • María Ferreras Forcada
  • Laura Francisco Gonzalez
  • Mónica García Lotero
  • Adrian Garcia Ron
  • Celia Gil López
  • Cristina Gonzalez Menchen
  • Javier Gutierréz Corral
  • José Reynaldo Homen Fernández
  • Marta Illan Ramos
  • Diego López De Lara
  • Mª Blanca Menéndez Prieto
  • Félix Moreno Barahona
  • Ana Muñoz Gómez
  • África Ndong Bindang
  • Maria Jose Nuñez Orantos
  • Susana Olmedo Hernández
  • Eva Orviz García
  • Olga Pérez Rodríguez
  • Maria Del Juncal Perez-Somarriba Moreno
  • Maria Teresa Puerta López
  • Javier Rodriguez Añover
  • Santiago Rueda Esteban
  • Sergio Sabogal Alvis
  • María Nieves Sanz Pérez
  • Adrián Valls Carbó
  • Mª Del Mar Vera García

Publications

Projects