Group information

The team has been working on a multidisciplinary basis since the late 1970s. It was initially made up of specialists from the Psychiatry, Neurophysiology, Nuclear Medicine, and Endocrinology Departments of the Hospital Clínico San Carlos, with a common interest in Neuroscience. Over time, the group has been structured and has grown with the participation of physicians from the Neurology and Geriatrics Departments. The result has been an extensive clinical, teaching, and research activity in different pathologies in this field, with the first publications appearing in 1979. Since 2000 the team has had a Molecular Genetics Research Laboratory within the Research Unit of the Hospital Clínico San Carlos and since the beginning of 2010 the Head of the Magnetoencephalography Centre of the Polytechnic University of Madrid has joined the group, thus responding to the current need to incorporate new technologies in the field of neuroimaging and genetics in our multidisciplinary line of research. Our activity is based on the two lines of research that we carry out:

• Study of the biological basis and genetic susceptibility of neuropsychiatric diseases: Study of cognitive alterations and their relationship with genetic and functional brain imaging markers in dementia, bipolar disorder, and schizophrenia.
• Genetic, cognitive, and neuroimaging markers of progression from mild cognitive impairment to dementia: Identification of gene variants involved in the pathophysiology of dementia, inflammation, and brain connectivity, as well as early cognitive and brain neuroimaging defects that may be predictors of progression to dementia in subjects with mild cognitive impairment. Study of anatomical and functional connectivity in patients with mild cognitive impairment and Alzheimer’s disease.