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Assessment of Diagnostic and Therapeutic Technologies in Coronary Arteriosclerosis

Assessment of Diagnostic and Therapeutic Technologies in Coronary Arteriosclerosis

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PRINCIPAL INVESTIGATOR

Escaned Barbosa, Javier
escaned@secardiologia.es
Tel. +34 913303000 (Ext. 484595)
ADDRESS

Cardiology Service

San Carlos Clinical Hospital
C/ Profesor Martín Lagos s/n.
28040 Madrid

Group information

To position the HUSC as the national reference centre for technology assessment studies and therapeutic strategies in patients with coronary arteriosclerosis.

Initiate lines of translational research to assess the results of new revascularisation or percutaneous diagnostic technologies tested in animal models in patients with ischaemic heart disease.

To conduct research of excellence leading to the publication of research results in scientific publications ranked in the impact factor third tercile, in the field of cardiovascular diseases.

Review

Prof. Javier Escaned is Head of the Interventional Cardiology Section at Hospital Clinico San Carlos / Complutense University (Madrid, Spain). He trained in the United Kingdom (Queen Elizabeth University Hospital, Birmingham and Walsgrave Hospital, Coventry) and The Netherlands (Thoraxcenter / Rotterdam) where he obtained his PhD degree in 1994. He is author of over 450 indexed scientific articles on interventional cardiology, imaging and physiology (h-index 67). He is Deputy Editor of the European Heart Journal, Advisory Editor of Eurointervention, and editor of the textbooks “Coronary Stenosis. Imaging, Structure and Physiology” and “Physiological Assessment of Coronary Stenoses and the Microcirculation), Recent or current ESC board positions include EAPCI and the ESC Working Group of Coronary Pathophysiology and Microcirculation. Recent trials as principal investigator include ADVISE II, DEFINE FLAIR and SYNTAX II. Additional interests are education and music.

Strategic objectives

Study of the influence of local (e.g., atheroma plaque composition) and systemic (e.g., diabetes, cardiovascular risk factors, coronary syndrome, etc.) factors on vascular response and long-term outcome of coronary revascularisation.
Assessment of the immediate and long-term vascular response to interventions, taking into account the degree of vascular damage associated with the revascularisation technique (assessed with intracoronary imaging techniques).
Assessment of the integrity of the coronary microcirculation after the use of revascularisation technologies (distal protection, preserved endothelial function, etc).

Lines of research

Assessment of the applicability of coronary revascularisation techniques in specific patient subgroups and coronary lesions. Examples of such subgroups include diabetic or renal failure patients, acute coronary syndromes, stenosis with thrombus, chronic occlusions, saphenous vein grafts, diffuse coronary artery involvement, restenotic lesions, and calcified stenosis.
Comparison of mechanical behaviour between in vitro and in vivo intracoronary prostheses (elastic recoil after stent implantation, etc.).
Evaluation of biodegradable endocoronary prostheses.
Assessment of intracoronary drug delivery systems (antiproliferative or antithrombotic drug-eluting balloons, proteolytic agents in chronic occlusions, etc).
Assessment of the need and type of revascularisation with the support of intracoronary diagnostic techniques (pressure wire, ultrasound, or intravascular optical coherence tomography): selection of candidates for a revascularisation technique, optimisation of the results of the technique, etc.